Manual assertion inferred by curator fromi,
Manually curated information which has been propagated from a related experimentally characterized protein.
UniProtKB.However UniProtKB may contain entries with identical sequences in case
Protein knowledgebase. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)),This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.
,This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
,This section is used to point to information related to entries and found in data collections other than UniProtKB.
,This section provides general information on the entry.
,This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Cyclic redundancy and other checksums
It is useful for tracking sequence updates.
The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,Inferred from Direct Assay
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, PIRSF; a whole-protein classification database, Simple Modular Architecture Research Tool; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. The algorithm is described in the ISO 3309 standard. , Phosphoserine; by PKA and PKB/AKT1 or PKB/AKT2, Manual assertion inferred from combination of experimental and computational evidence,This subsection of the PTM / Processing section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the 'Disulfide bond' subsection.
, Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate,This subsection of the PTM/processing section describes post-translational modifications (PTMs).
,This subsection of the Function section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.
. This subsection complements the information provided at the sequence level or describes modifications for which position-specific data is not yet available.. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.,This section provides any useful information about the protein, mostly biological knowledge.
,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Acetyl-CoA is also required for acetylat … We'd like to inform you that we have updated our Privacy Notice to comply Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),
Information which has been imported from another database using automatic procedures.
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Phosphorylation results in activation of its activity (By similarity). ATP-citrate lyase links cellular metabolism to histone acetylation Science. 2.3.3.8.Manually curated information for which there is published experimental evidence.
Sequence archive. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.,This section provides any useful information about the protein, mostly biological knowledge.
. x; UniProtKB. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. This is known as the 'taxonomic identifier' or 'taxid'.,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism.
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